Upstream processing is the earliest stage in biomanufacturing.


Upstream processing is the earliest stage in biomanufacturing that involves propagating mammalian, yeast, insect or microbial cells for producing desired products such as antibiotics, amino acids, therapeutic proteins, vaccines and viral vectors for gene therapy. In order for upstream processing to occur, appropriate nutrients must be available and stable growth environments must be tightly regulated to support the growth of these cells. Slight changes in cell cultivation environments can result in toxic accumulations that can negatively impact the viability, quality and yield of the final product. In our Upstream Processing courses, students will learn key nutritional and growth conditions via hands-on experience in media preparation and through the operation of microbial fermenters and mammalian cell culture systems. 

Online Courses

BioNetwork has several online courses.

Training Solutions
View All Courses: Upstream
Operations in Biotechnology Processes: An Overview
This course will focus on the details of the typical processing procedures utilized to produce a... more
Biomanufacturing Bootcamp
This course allows participants to experience biopharmaceutical manufacturing through lectures and... more
Biopharmaceutical fermentation involves propagating mammalian, yeast, or microbial cells to produce... more
Fundamentals of Biomolecules
Biomolecules are often the end product and a critical component of the bioprocessing and... more
Operations in Biotechnology Processes: An Overview
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Delivering a new pharmaceutical to the market is a very time-consuming and expensive process that... more
This interactive lesson examines the basic concepts of Environmental Monitoring. You will explore... more
In this interactive activity you will explore the process of fermentation, the equipment used, and... more
Explore the concepts and components of filtration in this interactive lesson. Then use that... more