Oral Solid Dose (OSD) Manufacturing

Oral Solid Dose (OSD) Manufacturing

The Oral Solid Dose (OSD) manufacturing course is the perfect training solution for all employees within pharmaceutical manufacturing industry at all levels to gain a fast and comprehensive understanding of the tablet and capsule manufacturing process - from powder to pill. This is especially useful for those who are operators in this field. All North Carolina OSD manufacturers are eligible to participate.  

Our 20-hour course (over 2.5 days) examines each unit dose operation and equipment for formulation, blending, granulation, milling, tableting, tooling, coating, encapsulation, and troubleshooting tablet defects.

The course is offered exclusively at the Pharmaceutical Services Network OSD facility located at Pitt Community College in Greenville, NC. The facility opened in 2018 and is commissioned with modern, industry-grade equipment.

Audience

  • All North Carolina OSD manufacturing companies are eligible to participate.
  • The course is designed to serve employees at all levels of production including new hires, recent transfers, managers, QA, R&D, supervisors, leads, and operators.
  • The course accommodates up to 16 participants at one time.

Topics Include

  • Active pharmaceutical ingredients and excipients
  • Wet and dry granulation techniques
  • LOD-water content, bulk density, particle size distribution, and angle of repose granule testing
  • Flow optimization through milling
  • Particle interactions based on size, distribution, shape, surface texture, cohesivity, surface coating, particle interaction, electrostatic charge, compaction recovery, and attrition
  • Weight control, setup, compression, and operation of a tablet press
  • Coating to improve a tablet’s strength, taste, color, handling, and sustained release characteristics
  • Troubleshooting tablet defects such as laminating, chipping, double pressing, picking, and friability
  • Tooling calibration of punches and dies
  • Operation of the tablet press to produce oral solid dose tablets
  • Capsule filler operation
  • FDA regulations, cGMP, safety, and documentation requirements

Learning Objectives

  • Understand the principles of the tablet and capsule manufacturing process.
  • Successfully manufacture oral solid dose drugs from powder to pill.
  • Apply cGMP principles to think critically, troubleshoot, and problem solve.
  • Communicate more effectively with other manufacturing groups within the company.  
  • Understand how OSD machines operate and why one technology is preferred over another.
Oral Solid Dose (OSD) Manufacturing

Level: Intermediate

Lecture HoursLab or Activity HoursTotal

Delivery Options

Face-to-Face
Delivered in a classroom or lab setting.

College Options

Colleges that are able to offer this course.

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